Gleevec, an Abl Family Inhibitor, Produces a Profound Change in Cell Shape and Migration
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چکیده
منابع مشابه
Family change and migration in the life course: An introduction
This article is an introduction to Special Collection 6 of Demographic Research whose articles investigate the interrelations between the family and migration behaviour of individuals in industrialised countries. We first review the life-course approach and previous research on the interplay between family change and migration. We then describe the contribution of the articles in the collection...
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The integrins are a family of heterodimeric receptors that play a universal role in mediating the adhesion of cells to the extracellular matrix. As such, the differential interactions of the receptors at the front and back ends of the cell are important in regulating the migration of cells. Approximately one-half of the integrins recognize the canonical RGD motif found in fibronectin, and a sig...
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The Abl-family non-receptor tyrosine kinases are essential regulators of the cytoskeleton. They transduce diverse extracellular cues into cytoskeletal rearrangements that have dramatic effects on cell motility and morphogenesis. Recent biochemical and genetic studies have revealed several mechanisms that Abl-family kinases use to mediate these effects. Abl-family kinases stimulate actin polymer...
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BACKGROUND ABL tyrosine kinases control actin remodeling in development and in response to environmental stimuli. These changes affect cell adhesion, cell migration, and cell-cell contact. Little is known, however, about upstream mechanisms regulating ABL protein activation. RESULTS We report that the RAS effector RIN1 is an activator of ABL tyrosine kinases. RIN1 expression in fibroblasts pr...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0052233